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Science & Policy

What happens in the brain when cannabis makes you anxious?

Summary: Cannabinoids may intensify anxiety by removing a natural brake on specific neurons in the brain’s fear center, particularly during stressful situations.

Key points

  • Cannabinoids may intensify anxiety by removing a natural brake on specific neurons in the brain’s fear center, particularly during stressful situations.
  • In mice, shutting down those neurons sharply reduced cannabinoid-related anxious behavior.

Cannabinoids may intensify anxiety by removing a natural brake on specific neurons in the brain’s fear center, particularly during stressful situations. In mice, shutting down those neurons sharply reduced cannabinoid-related anxious behavior.

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