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Science & Policy

Scientists may have overlooked a hidden Alzheimer's culprit for decades

Summary: For decades, scientists have focused on amyloid beta as a major culprit behind Alzheimer’s disease, spending billions of dollars developing treatments that have often delivered disappointing results.

Key points

  • For decades, scientists have focused on amyloid beta as a major culprit behind Alzheimer’s disease, spending billions of dollars developing treatments that have often delivered disappointing results.
  • Now, researchers at UC Santa Cruz are drawing attention to a largely overlooked peptide called P3 that could also play a role in the disease.
  • Previously believed to be harmless, P3 can form harmful-looking protein clumps even faster than amyloid beta and may also damage brain cells.

For decades, scientists have focused on amyloid beta as a major culprit behind Alzheimer’s disease, spending billions of dollars developing treatments that have often delivered disappointing results. Now, researchers at UC Santa Cruz are drawing attention to a largely overlooked peptide called P3 that could also play a role in the disease. Previously believed to be harmless, P3 can form harmful-looking protein clumps even faster than amyloid beta and may also damage brain cells.

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